The Best Pain Relief Sprays of 2025: A Comprehensive Review

We've researched and tested variety of pain relief sprays, and have compiled a list of the top options based on effectiveness, ease of use, and overall value.
Joint Health Magazine is supported by our readers. When you buy something through a link on this page, we may earn an affiliate commission. See our Advertiser Disclosure.
The Best Pain Relief Sprays of 2025: A Comprehensive Review

How We Pick The Best Pain Relief Sprays?

Our expert team evaluates each pain relief spray through multiple testing phases. Medical professionals assess the active ingredients in every spray formulation. Professional testers measure the absorption rate and effectiveness of each product consistently.

Quality control experts verify manufacturing standards and safety certifications from recognized authorities. Industry specialists compare pricing structures to determine the best value options available. Laboratory technicians analyze the concentration levels of key therapeutic components in sprays.

Our Top Picks For Best Pain Relief Sprays

Editor's Choice Award #1Biofreeze Spray

Biofreeze Spray
Reviews
(4.0/5)

$10.86

Buy On Amazon
Buy On Walmart

Highlights

  • Hard-to-reach regions can be evenly and mess-free covered thanks to the 360-degree brush.
  • With menthol as an active component, Biofreeze Spray quickly relieves minor muscular and joint discomfort.
  • Use Biofreeze Spray as a spot treatment for localized discomfort or as a massage oil on bigger muscle groups.
  • When used as instructed, Biofreeze Spray is usually regarded as secure with a minimal chance of adverse reactions.
  • FORM: Spray
  • BRAND: Biofreeze
  • DOSAGE: Spray 3 to 4 Times
  • VOLUME: 4 Fl Oz
  • INGREDIENTS: Menthol, Arnica Montana flower extract, Calendula flower extract, Camellia Sinensis leaf extract, etc.
  • CONTACT: 1245 Home Avenue, Akron, Ohio 44310, United States, 866-682-4639, [email protected].
Customer Reviews

Customer Rating
“Biofreeze Spray has been a game-changer for me in controlling my chronic shoulder discomfort for a few weeks now. It is simple to apply to difficult-to-reach regions thanks to the 360-degree applicator, and the menthol offers fast-acting comfort without any odors or residue. I also value the fact that using it is usually thought to be secure and non-invasive. The ease of the spray, in my view, more than makes up for the fact that it doesn’t seem to last as long as the gel composition. ~ Brooks

The Bottom Line

Editor's Choice Award #2Aspercreme Spray

Aspercreme Spray
Reviews
(3.9/5)

$10.48

Buy On Amazon
Buy On Walmart

Highlights

  • This Spray comes in a canister, making it simple to administer the medicine in a thin coating to the afflicted region.
  • Most skin types can use the composition because it doesn’t irritate them.
  • Lidocaine, the active component in this Spray, offers quick pain alleviation for mild aches and injuries.
  • The spray’s spray composition offers a practical choice for pain alleviation while traveling or in difficult-to-reach places.
  • FORM: Spray
  • BRAND: Aspercreme
  • DOSAGE: Spray 3 Times Daily
  • VOLUME: 4 Fl Oz
  • INGREDIENTS: Lidocaine HCl, Alcohol Denat.
  • CONTACT: P.O. Box 2219 Chattanooga, TN 37409-0219, 1-800-633-1610.
Customer Reviews

Customer Rating
For a few weeks now, I’ve been using the Aspercreme Lidocaine Pain Relief Dry Spray, and I’m really happy with it. The spray makes applying the medicine to the afflicted region simple and hassle-free. Fast-acting pain relief is provided by the lidocaine, which is excellent for my sporadic bruises and muscular sprains. The only drawback is that I have to re-apply after a few hours because the comfort doesn’t last as long as I’d like. Overall, I’m pleased with the product’s usefulness and efficiency. ~ Sarah
Read Full Reviews

The Bottom Line

Editor's Choice Award #3Icy Hot Spray

Icy Hot Spray

Highlights

  • The cooling and warming feelings of Icy Hot Spray quickly relieve minor to severe muscular and joint discomfort.
  • Icy Hot Spray is a practical choice for pain alleviation while traveling because it is simple to use and doesn’t leave any traces.
  • Since Icy Hot Spray is sold without a prescription, it is a convenient and affordable choice for pain management.
  • FORM: Spray
  • BRAND: Icy Hot
  • DOSAGE: Spray 3 to 4 Times Daily
  • VOLUME: 4 Fl Oz
  • INGREDIENTS: Menthol, Camphor, Lidocaine HCl, Methyl salicylate, Carbomer, Cetearyl alcohol.
  • CONTACT: Chattem Inc., P.O. Box 2219, Chattanooga, TN 37409-0219.
Customer Reviews

Customer Rating
Icy Hot Spray is helping my lower back discomfort a lot, and I’ve been using it for a few days now. My aching muscles are soothed by the chilling and warming sensations that the menthol and camphor produce. When I need immediate comfort while traveling, the spray is excellent because it is simple to use and doesn’t make a mess. I do, however, discover that the benefits disappear fairly rapidly, necessitating a reapplication after a few hours. Overall, I’m pleased with this product’s ability to meet my mild- to moderate-pain alleviation requirements. ~ Kyle
Read Full Reviews

The Bottom Line

Editor's Choice Award #4Salonpas Spray

Salonpas Spray
Reviews
(3.9/5)

$11.60

Buy On Amazon
Buy On Walmart

Highlights

  • Localized discomfort in muscles and joints can be treated with Salonpas Spray.
  • Since Salonpas Spray doesn’t require any messy application or cleanup, it’s a practical choice for pain alleviation while on the go.
  • Because it includes (NSAIDs), it is a good alternative for people who cannot or do not want to take dietary painkillers.
  • Numerous painful conditions, such as rheumatism, injuries, and strains, can be treated with Salonpas Spray.
  • FORM: Spray
  • BRAND: Salonpas
  • DOSAGE: Spray 3 to 4 Times Daily
  • VOLUME: 4 Fl Oz
  • INGREDIENTS: Methyl salicylate (10%), Menthol (3%), Glycerin, Propylene glycol, Benzyl alcohol, Sodium stearate, etc.
  • CONTACT: Hisamitsu Pharmaceutical Co, Otemachi, Chiyoda-ku, Tokyo 100-0004, Japan,1 (800) 826-8861.
Customer Reviews

Customer Rating
Since I’ve started using Salonpas Spray, my arthritic discomfort has significantly decreased. My joints are soothed by the chilling and warming effects that methyl salicylate and peppermint produce. I do, however, find that the spray’s fragrance can occasionally be a bit overwhelming, so I typically have to use it in a space that is well-ventilated. Overall, I’m satisfied with Salonpas Spray’s ability to relieve my arthritic discomfort and its practicality. ~ Glenn
Read Full Reviews

The Bottom Line

Editor's Choice Award #5Dermoplast Spray

Dermoplast Spray

Highlights

  • A pain-relieving mist called Dermoplast mist can be applied to small burns, bug stings, sore throats, and gum irritations.
  • Benzocaine, the main component of Dermoplast spray, has a numbing impact that may aid to lessen discomfort.
  • Dermoplast Spray is a flexible choice for many people because it can be used for a variety of pain and discomfort problems.
  • FORM: Spray
  • BRAND: Emerson Healthcare
  • DOSAGE: Spray 3 to 4 Times Daily
  • VOLUME: 2.75 Fl Oz
  • INGREDIENTS: Benzocaine (20%), Menthol (0.5%), Acetylated Lanolin Alcohol, Aloe Vera Gel (Decolorized), Butane, etc.
  • CONTACT: Cedar Knolls, NJ 07927 USA, 1-800-345-0032, [email protected].
Customer Reviews

Customer Rating
Recently, I used Dermoplast Spray to treat a small injury on my hand, and I was pleasantly surprised by how well it worked. The spray was simple to use and fuss-free to apply, and the benzocaine had a numbing effect that served to lessen the pain and soreness. The relief it offered lasted for several hours, and I appreciated that it didn’t have a powerful scent or sting like some other burn treatment sprays I’ve used in the past. ~ Matthew
Read Full Reviews

The Bottom Line

Editor's Choice Award #6Aleve Spray

Aleve Spray

Highlights

  • Fast-acting pain and stiffness alleviation is provided by AleveX Pain Relieving Spray for muscles and joints.
  • Long-lasting comfort is intended to be achieved by the mist without the need for repeated application.
  • In contrast to some other painkilling sprays, AleveX is made to work without spilling or making a disturbance.
  • It is simple to apply to difficult-to-reach regions and offers a hands-free application thanks to the spray container design.
  • FORM: Spray
  • BRAND: Bayer Consumer Health
  • DOSAGE: Spray 3 to 4 Times Daily
  • VOLUME: 3.02 Fl Oz
  • INGREDIENTS: Camphor 2.11%, Menthol 16%, Butane, Crospovidone, Eucalyptus Globulus Leaf Oil, Isobutane, etc.
  • CONTACT: P.O. Box 811930, Boca Raton, FL 33481-1930.
Customer Reviews

Customer Rating
After working out, I recently tested AleveX Pain Relieving Spray on my aching muscles and was pleasantly surprised by how well it worked. Unlike other muscle sprays I’ve tried that have a powerful fragrance, this one was simple to use and had a nice scent. It offered immediate comfort that endured for several hours, and I valued the hands-free application that made it simple for me to reach difficult-to-reach places like my back. Overall, if you’re experiencing muscular pain, I would certainly suggest trying AleveX Pain Relieving Spray. ~ Jason
Read Full Reviews

The Bottom Line

Editor's Choice Award #7Theraworx Spray

Theraworx Spray
Reviews
(3.7/5)

$17.99

Buy On Amazon
Buy On Walmart

Highlights

  • Theraworx Relief Spray is made to offer effective, quick relief from muscular contractions and pains.
  • The spritz has a soft, non-stinging foam texture that dissipates right away without leaving behind any sticky residue or overpowering flavor.
  • The effectiveness of the substance in treating muscle cramps and spasms has been demonstrated in numerous clinical trials.
  • It has organic components, such as magnesium and other nutrients, that support the body’s natural mending processes.
  • FORM: Spray
  • BRAND: Theraworx
  • DOSAGE: Spray 6 to 8 Times Daily
  • VOLUME: 7.1 Fl Oz
  • INGREDIENTS: Magnesium Sulfate 6x, Colloidal Silver, Citrus Grapefruit Extract, Aloe, Allantoin 0.5%, and Vitamin E.
  • CONTACT: 4 Old Patton Cove Road, Swannanoa, NC 28778, [email protected], 888-282-7353.
Customer Reviews

Customer Rating
I’ve been using Theraworx Relief Spray to treat muscular aches and twitches for a while, and I’ve discovered it to be very successful. Because it dissolves rapidly and doesn’t leave behind any sticky residue, I adore the foam composition. In contrast to other muscle sprays, which have a powerful fragrance, it also has a pleasant flavor, which is definitely a bonus. It employs natural ingredients like magnesium, which I respect, and I’ve discovered that it rapidly eases my muscular cramps. ~ Marcus

The Bottom Line

Editor's Choice Award #8TIDL Spray

TIDL Spray
Reviews
(3.7/5)

$19.95

Buy On Amazon
Buy On Walmart

Highlights

  • Direct application of the mist will target the area’s discomfort and reduce swelling and pain.
  • TIDL Spray can provide relief rapidly, enabling you to continue your everyday tasks in greater comfort.
  • There is no need for messy cold bags or gels thanks to the spray container, which makes it simple to administer the product.
  • With no need for drugs or meds, TIDL Spray is a non-invasive therapy choice that lowers the possibility of adverse effects.
  • FORM: Spray
  • BRAND: TIDL
  • DOSAGE: Spray 6 to 8 Times Daily
  • VOLUME: 3 Fl Oz
  • INGREDIENTS: Menthol, Arnica Montana Flower Extract, Beta-Caryophyllene, Calendula Officinalis Flower Extract.
  • CONTACT: Visit Website.
Customer Reviews

Customer Rating
The TIDL Spray is simple to use, has a pleasant cooling sensation, and offers prompt pain relief. However, I wish the results persisted longer. Fair enough, it won’t solve the issue because I’m using it on an arthritic knee. It does alleviate transferred pain in the neighborhood. ~ Watson
Read Full Reviews

The Bottom Line

Editor's Choice Award #9Blu Emu Spray

Blu Emu Spray
Reviews
(3.6/5)

$12.00

Buy On Amazon
Buy On Walmart

Highlights

  • Blu Emu Spray can quickly and precisely relieve your discomfort so you can resume your normal activities with ease.
  • You can use the spray while on the go without feeling greasy or sticky because it is made to evaporate fast and leave no trace.
  • Emu oil, aloe vera, MSM, and glucosamine are ingredients in the mist that can ease joint and muscular pain.
  • Blu Emu Spray’s pain-relieving effects may last for several hours, enabling you to engage in your tasks pain-free.
  • FORM: Spray
  • BRAND: Blu Emu
  • DOSAGE: Spray 3 to 4 Times Daily
  • VOLUME: 4 Fl Oz
  • INGREDIENTS: Emu oil, Aloe Vera, MSM, Glucosamine, Trolamine salicylate.
  • CONTACT: 100 18th Street, Bristol, TN 37620, 1-800-432-9334
Customer Reviews

Customer Rating
I suffer from post-polio syndrome, avascular necrosis from chemotherapy in my left hip and shoulder, three left hip implants, and ongoing discomfort. I first learned about the Blue Emu many years ago. tried it, and I’ve been using it every day ever since. Blu Emu is always there, no matter where I am. I appreciate you making it accessible. ~ Simond
Read Full Reviews

The Bottom Line

Editor's Choice Award #10Tiger Balm Spray

Tiger Balm Spray

Highlights

  • For those who require immediate relief, Tiger Balm Spray is an excellent choice because it can relieve pain efficiently and swiftly.
  • It can be applied before and after exercise, as a warm-up for sports, or it can be used to relieve aching muscles and joints.
  • Tiger Balm Spray’s composition is made to be non-greasy and quickly dissolved, so you won’t feel gummy or oily after using it.
  • Tiger Balm Spray’s painkilling effects can last for several hours, which can help you avoid pain for extended amounts of time.
  • FORM: Spray
  • BRAND: Har Paw Healthcare
  • DOSAGE: Spray 3 to 4 Times Daily
  • VOLUME: 4 Fl Oz
  • INGREDIENTS: Methyl salicylate 30%, Alcohol denatured, Aqua, Camphor, Menthol, Eucalyptus globulus leaf oil, etc.
  • CONTACT: 751 North Canyons Parkway, Livermore, CA 94551, 1 (925) 292-3888.
Customer Reviews

Customer Rating
Over the years, I’ve tried a ton of various painkillers, and I have to say that Tiger Balm Spray is one of the finest. Simply spray it on and massage it in for instant muscular pain or stiffness alleviation. It’s ideal for those moments when you need it most. It works fantastically for both moderate and severe pain, and unlike some other pain relief sprays, it doesn’t have that overpowering medical scent. The only drawback is that it’s more expensive than most over-the-counter painkillers, but in my view, it’s still worth the money. ~ Alex
Read Full Reviews

The Bottom Line

What To Look For Before Buying Pain Relief Sprays?

Smart consumers examine the concentration percentages of active ingredients before making purchases. Menthol provides cooling relief, while capsaicin delivers warming comfort to sore muscles.

Natural anti-inflammatory compounds work effectively without causing unwanted side effects. Quick absorbing formulas penetrate deeply to target pain points beneath the skin. Non-greasy applications allow people to continue daily activities without residue or stains.

Long-lasting relief eliminates the need for frequent reapplication throughout busy days. The spray bottle design affects the ease and accuracy of product application. Continuous spray mechanisms deliver even coverage in too difficult-to-reach areas.

Quality packaging preserves the active ingredients and maintains proper spray pressure over time. Clear usage instructions help consumers apply the correct amount for optimal results. Child-resistant caps provide important safety features for households with young children.

How Do These Pain Relief Sprays Work For Pain?

Pain relief sprays utilize specialized delivery systems to target discomfort in specific areas. Cooling ingredients like menthol bind to cold receptors to reduce pain signal transmission. Warming compounds increase local blood flow to promote natural healing processes.

Anti-inflammatory agents decrease swelling and provide relief from joint stiffness. Analgesic components interrupt pain signals traveling through the peripheral nervous system. The sprays create a protective barrier that allows active ingredients to penetrate.

Specialized carriers transport therapeutic compounds through multiple layers of skin tissue. Time-release formulas provide sustained relief over several hours of activity. Multiple mechanism products combine different active ingredients for enhanced effectiveness. Targeted application allows higher concentrations of medicine exactly where people need relief.

What Are The Side Effects Of Pain Relief Sprays?

Most users tolerate pain relief sprays well when following proper application instructions. Some people experience mild skin sensations like cooling or warming effects. Temporary redness might occur at the application site but typically resolves quickly.

Sensitive individuals should test products on small areas before widespread use. Proper ventilation prevents respiratory irritation from strong menthol formulations. Medical professionals recommend avoiding broken skin or open wound applications.

People taking blood thinners should consult doctors before using salicylate containing products. Pregnant women need physician approval before starting any new pain relief regimen. Some formulas might interact with prescription medications or other topical treatments. Regular monitoring helps identify any developing sensitivities or reactions early.

How To Pick Best Pain Relief Spray For Your Joint Pain?

People experiencing joint pain benefit from products containing proven anti-inflammatory compounds. Fast acting formulas provide quick relief during acute pain episodes or flares. Long-lasting products maintain comfort throughout extended activity or work periods.

Easy application designs allow precise targeting of affected joints and areas. Regular use helps manage chronic conditions and maintains joint mobility effectively. Medical professionals can recommend specific formulations based on individual conditions.

Natural ingredient options provide gentle relief without harsh chemical compounds. Professional athletes choose sports specific formulas for performance and recovery support. Arthritis focused products address both pain and joint health maintenance needs. Multiple package sizes accommodate different usage patterns and storage requirements.

Why Trust Joint Health Magazine?

Our medical review board validates all product claims and ingredient effectiveness statements. Independent laboratory testing confirms product quality and ingredient concentration levels consistently.

Professional healthcare providers contribute practical insights from clinical experience with various products. Consumer feedback analysis reveals real-world performance and satisfaction levels accurately.

Regular content updates incorporate new product developments and clinical findings promptly. The editorial team maintains strict quality standards for all published information. Product evaluations follow standardized protocols to ensure consistent assessment methods.

Multiple experts review each article before publication to verify accuracy thoroughly. Transparent disclosure policies identify any potential conflicts of interest clearly. Reader questions receive prompt responses from qualified healthcare professionals regularly.

Product Comparison

To help you decide, here is a brief comparison of our top picks:

Biofreeze Spray Aspercreme Spray Icy Hot Spray Salonpas Spray Aleve Spray
Price/Shipping $10.86 + Free Shipping $10.48 + Free Shipping $7.56 + $3 to $4 $11.60 + $2 to $3 $8.99 + $5 to $6
User Rating 4.0/5 3.9/5 3.8/5 3.9/5 3.8/5
Third Party Tested Yes No No Yes No
Return Policy 30 Days 30 – 90 Days 30 – 90 Days Non-Returnable 30 Days
Benefits Provides a Numbing Sensation To Reduce Discomfort in Sore Muscles or Joints* Provides Fast-Acting, Temporary Relief of Minor Pain Associated with Arthritis* Provide a Soothing Effect on Sore Areas of the Body* Salonpas Jet Spray Dries Quickly and Is Non-Greasy* Provides Fast-Acting and Long-Lasting Targeted Pain Relief*
Certifications Sport program Certified/FDA Approved Not Certified Sport program Certified/NSF Certified ISO/GMP Certified Not Certified
Buying Options Amazon Amazon Amazon Amazon Amazon

Author

Andrew Ossa, RD, CDNC is a Bilingual Registered Dietitian from sunny Southern California. He currently specializes in renal nutrition and personalized nutrition coaching.

 
X

How helpful was it?

icon This article changed my life!
X

How helpful was it?

icon This article changed my life! Change
Your Rating
Note: Joint Health Magazine isn't a healthcare provider. We can't respond to health questions or give you medical advice.
Your Privacy is important to us.
icon This article was informative. icon I have a medical question.
X

How helpful was it?

icon This article was informative. Change
Your Rating
Note: Joint Health Magazine isn't a healthcare provider. We can't respond to health questions or give you medical advice.
Your Privacy is important to us.
X
icon I have a medical question. Change

We’re unable to offer personal health advice, but we’ve partnered with JustAnswer who offers on-demand doctors to answer your medical questions 24/7. Talk online now with a doctor and get fast 1-on-1 answers from the comfort of your couch.

just answer logo
ASK A DOCTOR NOW

If you’re facing a medical emergency, call your local emergency services immediately, or visit the nearest emergency room or urgent care center.

X

How can we improve it?

icon This article contains incorrect information.
X

How can we improve it?

icon This article contains incorrect information. Change
Your Rating
Note: Joint Health Magazine isn't a healthcare provider. We can't respond to health questions or give you medical advice.
Your Privacy is important to us.
icon This article doesn’t have the information I’m looking for. icon I have a medical question.
X

How can we improve it?

icon This article doesn’t have the information I’m looking for. Change
Your Rating
Note: Joint Health Magazine isn't a healthcare provider. We can't respond to health questions or give you medical advice.
Your Privacy is important to us.
X
icon I have a medical question. Change

We’re unable to offer personal health advice, but we’ve partnered with JustAnswer who offers on-demand doctors to answer your medical questions 24/7. Talk online now with a doctor and get fast 1-on-1 answers from the comfort of your couch.

just answer logo
ASK A DOCTOR NOW

If you’re facing a medical emergency, call your local emergency services immediately, or visit the nearest emergency room or urgent care center.